HIV/AIDS
« Previous EntriesSimplified Darunavir Therapy Successful in Experienced Patients
Tuesday, February 23rd, 2010Once-daily dosing of the protease inhibitor darunavir (Prezista) appeared to be at least as effective as twice-a-day regimens among treatment-experienced patients with no darunavir-associated resistance mutations, researchers reported here.
Study subjects received an optimized nucleoside backbone regimen and were randomized to either once- or twice-daily darunavir boosted with ritonavir.
Some 72.1% achieved undetectable HIV viral load on […]
Study shows protease inhibitors more forgiving of missed doses, even when treatment out of date
Thursday, February 4th, 2010Less than perfect adherence to HIV treatment regimens significantly increases the risk of resistance developing to drugs in the NNRTI and NRTI classes, investigators report in the January 28th edition of AIDS.
Poor adherence to boosted protease inhibitors did not, however, involve a significant risk of resistance.
Adherence is the single most important factor under […]
Gilead says experimental four-drug HIV regimen works as well as Atripla.
Thursday, January 7th, 2010The AP (1/6) reported, “Gilead Sciences Inc. said Wednesday its experimental four-drug HIV regimen is working as well as its current drug cocktail in a mid-stage clinical trial.” The experimental regimen includes the “drugs called elvitegravir and GS 9350, as well as the combination drug Truvada [emtricitabine/tenofovir].” In a trial “scheduled to last 48 weeks,” […]
Findings on viral rebound discourage quick drug switches in resource-limited settings
Wednesday, December 2nd, 2009Source: AIDSmap.com
A South African study found that viral resuppression occurred in 41% of people who continued taking the same antiretroviral drug regimen after experiencing a viral load increase on treatment.
The retrospective cohort analysis, reported in the December 15th edition of Clinical Infectious Disease, also documented the accumulation of resistance mutations over time. Nucleoside reverse […]
Sperm May Play Leading Role In Spreading HIV
Monday, October 26th, 2009Source: ScienceDaily
Sperm, and not just the fluid it bathes in, can transmit HIV to macrophages, T cells, and dendritic cells (DCs), report a team led by Ana Ceballos at the University of Buenos Aires in Argentina. By infecting DCs, which carry the virus and potently pass it to T cells, sperm may play a leading […]
