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Antihypertensive combination therapy effective for slowing progression to CKD.

By Jeremy Cockerill | February 18, 2010

Source: DIA Daily

HeartWire (2/17, O’Riordan) reported that, according to a study published online Feb. 18 in The Lancet, “antihypertensive combination therapy with the ACE inhibitor benazepril plus the calcium-channel blocker amlodipine (Lotrel, Novartis) is more effective than treatment with the ACE inhibitor and a diuretic for slowing the progression to chronic kidney disease (CKD).” In a study of “11,506 men and women aged 55 years or older who had systolic blood pressure >160 mm Hg,” researchers found that “113 patients in the benazepril/amlodipine arm progressed to CKD, compared with 215 patients treated with the benazepril/hydrochlorothiazide combination.”